The Dutchman completed a six-month loan move to the club on Saturday but was not registered in time to face Manchester City.
The 30-year-old had been on loan at Besiktas from Burnley but the Turkish club agreed to end his deal with them in order to let the striker join the Red Devils, who paid a fee of around £2m.
Anthony Martial started in the win against City but he was forced to come off at half-time and he was not spotted as United’s squad flew to London last night.
Weghorst, though, was part of the travelling party after arriving with Christian Eriksen at Manchester Airport.
With Martial a potential absentee, Weghorst could start at Selhurst Park as United look to pile pressure on Arsenal ahead of Sunday’s trip to the Emirates.
United can cut the deficit to the Gunners down to six points by beating Palace, while they would also leapfrog rivals City before they face Tottenham at the Etihad.
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