Emma Raducanu is back at the scene of her famous victory 12 months ago, whilst Andy Murray returns to the tournament which saw him win his first Grand Slam title after a gruelling final against Novak Djokovic in 2012.
The pair will be joined in New York by the best British tennis has to offer, including world No 9 Cameron Norrie, fresh from his Wimbledon semi-final appearance earlier this year.
But which other players make up Team GB at the competition?
Which British players are competing at the US Open 2022?
Defending champion Raducanu enters the US Open after a year of struggles with fitness and form since lifting the Venus Rosewater Dish at Flushing Meadows last year.
The teenager has only made the second round in each of the Grand Slams since that dizzying night 12 months ago, and has suffered from blisters and rib problems in 2022.
Raducanu was spotted with tape on her right wrist and looked troubled during an uncomfortable practice session ahead of the US Open.
Harriet Dart is the only other female British player taking part in the US Open, after Heather Watson and Katie Boulter both lost in qualifying.
Dart broke into the top 100 for the first time in her career earleir this year, and had a strong showing at Indian Wells which should put her in good stead for her time in New York.
Murray has had injury problems of his own, after he limped off the court in his second round defeat to compatriot Norrie in Cincinnati.
He has not been seeded for the tournament and will face a tough run if he is to reach the second week of the slam.
Norrie, meanwhile, enters the US Open with a genuine chance of winning his first Grand Slam title after a brilliant 18 months which saw the British No 1 win the prestigious Indian Wells tournament in October of last year.
Jack Draper will be confident of a good run in the Big Apple after reaching his first Masters quarter-final in Montreal.
British players’ first round matches
The following are the first-round matches for the British players in the US Open 2022 – not that the British player names are in bold:
Monday, August 29:
Andy Murray vs Francisco Cerundolo (24) – 4pm
Kyle Edmund vs Casper Ruud (5) – 5.15pm
Harriet Dart vs Daria Kasatkina (10) – 7.15pm
Jack Draper vs Emil Ruusuvuori – 8.30pm
Tuesday, August 30:
Cameron Norrie (7) vs Benoit Paire – 4pm
Daniel Evans (20) vs Jiri Vesely – 5.15pm
Emma Raducanu (11) vs Alize Cornet – 12am
How to watch the US Open on TV in the UK
The US Open will be available for viewers in the UK to watch on Amazon Prime.
Those without access to the US Open can purchase Prime membership for £7.99 per month, or £79 for a whole year.
Tennis fans can also sign-up for a free 30-day Prime membership trial, after which full membership starts but can be cancelled at any time.
Live coverage will also be available on BBC Radio 5 Live and 5 Live Sports Extra.
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