The 44-year-old married the 39-year-old actress in 2015 and the couple share two children – daughter Wyatt Isabelle, 8, and son Dimitri Portwood, 6.
He admitted that due to their age gap while filming the sitcom that first aired in 1998, nothing romantic happened initially between the famous lovers.
Ashton starred in the iconic series during his 20s while Mila was only 14 when she joined the cast.
The star admitted his lack of attraction to his wife on Monday to The One Show hosts Alex Jones and Jermaine Jenas.
He appeared on the BBC fixture to promote his new film with Reese Witherspoon, Your Place or Mine.
‘We’re in a completely different place in our relationship now than where we were then’, Ashton explained.
The Two and a Half Men star continued: ‘When we were there, she was 15 years old, I was 20 years old, there was zero romantic connection between the two of us.’
Mila and Ashton recently returned to the set of the show as part of filming for their new spin-off Netflix series That ‘90s Show.
The husband and wife duo star in the new sitcom and revived their roles as Jackie Burkhart and Michael Kelso.
He said of the trip back to where it all began: ‘To go back and have it be this new shared experience was really wild and nostalgic and there’s so many memories that come alive like when you see the basement again or these characters that were so much a part of our lives for so long.
‘It was super nostalgic for us and really fun and I’m excited for these kids that are hopefully going to get to experience the same ride that we got to go on when we were their age.’
The famous faces decided to tie the knot in a private ceremony in Oak Glen, California, on July 4, 2015 after Mila gave birth to their first child together in October 2014.
The One Show airs weekdays on BBC One from 7pm.
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